Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial

Single repeated maintenance

 

Objective:

Subanesthetic ketamine doses have been shown to have rapid yet transient antidepressant effects in patients with treatment-resistant depression, which may be prolonged by repeated administration. The purpose of this study was to evaluate the antidepressant effects of a single ketamine infusion, a series of repeated ketamine infusions, and prolongation of response with maintenance infusions.

Methods:

Forty-one participants with treatment-resistant depression completed a single-site randomized double-blind crossover comparison of single infusions of ketamine and midazolam (an active placebo control). After relapse of depressive symptoms, participants received a course of six open-label ketamine infusions administered thrice weekly over 2 weeks. Responders, classified as those participants who had a ≥50% decrease in their scores on the Montgomery-Åsberg Depression Rating Scale (MADRS), received four additional infusions administered once weekly (maintenance phase).

As Seen On:

as seen on:

AS SEEN ON:

as seen on:

Mental healthcare Made for You

Bespoke Treatment Clinics offer alternative therapy that works for depression,
PTSD, anxiety and more.

THE TESTIMONIALS

Related Posts

READY FOR A BREAKTHROUGH

Your personalized plan is tailored to
your needs and schedule.

Your plan will be created based on what you need. 
Learn about our most common treatment options.

WELCOME

Are you looking for TMS & Brain Health?

You’re in the right place! We’ve changed our name and branding to emphasize our commitment to personalized mental healthcare.

Welcome to Bespoke Treatment.